Drought Demise Attribution Over CONUS

Drought return times in the Sahel: A question of attribution

[1] Recurrence times for extreme drought events in the African Sahel are estimated using a classical peaks-overthreshold model. Results, which are computed for both mean seasonal rainfall and fractional area in drought, suggest that the distribution of dry extremes after about 1970 is statistically distinct from that of preceding years. This finding throws into relief the critical role played b...

Conus medullaris stroke

Absent F wave in the stage of spinal shock has been described in cases of traumatic spinal cord injury. The role of F wave in predicting prognosis after conus medullaris infarct has not been described. We describe herein a middle aged-man with a conus medullaris infarct. Both tibial and peroneal F waves were absent on day 4. The left tibial F wave reappeared in the following study on day 18. Al...

Demise of the OTA.

Background: An impediment to the rational development of novel drugs against tuberculosis (TB) is a general paucity of knowledge concerning the metabolism of Mycobacterium tuberculosis, particularly during infection. Constraint-based modeling provides a novel approach to investigating microbial metabolism but has not yet been applied to genome-scale modeling of M. tuberculosis. Results: GSMN-TB...

The King's Demise

Conus venom peptide pharmacology.

Conopeptides are a diverse group of recently evolved venom peptides used for prey capture and/or defense. Each species of cone snails produces in excess of 1000 conopeptides, with those pharmacologically characterized (≈ 0.1%) targeting a diverse range of membrane proteins typically with high potency and specificity. The majority of conopeptides inhibit voltage- or ligand-gated ion channels, pr...